dna fragmentation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN3110	5-Geranoxy-7-methoxycoumarin		Anti-infection , Antibacterial , Antifungal
	5-Geranoxy-7-methoxycoumarin shows antifungal activity.		Anti-infection , Antibacterial , Antifungal
T6738	Z-FA-FMK		SARS-CoV , Cysteine Protease
	Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.		SARS-CoV , Cysteine Protease
T9743	FEN1-IN-SC13		Others
	FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)		Others
T4730	Thymidine-5'-monophosphate disodium salt	Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT	Others , Endogenous Metabolite
	Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) is found in DNA. In mammalian cells, thymidine deprivation induces chromosome aberrations such as chromatid breaks, chromatid interchanges, and chromosome frag...		Others , Endogenous Metabolite
T1772	MDK83190	Apoptosis Activator 2	Apoptosis , Caspase
	MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .		Apoptosis , Caspase
T68896	Daniquidone	NSC 320846,BAY-H 2049	Topoisomerase
	Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DNA fragmentation for the study of neoplasms, immune disorder...		Topoisomerase
T22812	GRI977143	GRI 977143	LPA Receptor
	GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation.		LPA Receptor
TN3049	4-Methoxycinnamyl alcohol		Others
	4-Methoxycinnamyl alcohol showed toxicity to MCF-7, HeLa and DU145 cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare. 4-Methox...		Others
T5S0636	Citric acid	Citro,Citretten	Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic
	1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili...
TN2496	1,4-Anthraquinone		Others
	1,4-Anthraquinone is an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar ...		Others
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T9113	Myristicin	Myristicine	IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase
	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ...
T25856	NC182	NC 182,NC-182
	NC182 is a topo II inhibitor that shows selective and potent topo II inhibition on the induction of topo II-dependent DNA fragmentation.
T69896	Sabarubicin	MEN 10755
	Sabarubicin, a doxorubicin disaccharide analogue, exhibits pronounced antitumor activity and surpasses doxorubicin in effectiveness as a topoisomerase II poison, promoting DNA fragmentation at reduced intracellular conce...
T62555	MMP-2/9-IN-1
	MMP-2/9-IN-1 (Compound 4a) is a potent dual inhibitor of MMP-2 (IC50: 56 nM) and MMP-9 (IC50: 38 nM). leading to DNA fragmentation.
T36324	C8 L-threo Ceramide (d18:1/8:0)	C8 L-threo Ceramide (d18:1/8:0)
	C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5...
T75645	Echitamine chloride
	Echitamine chloride, the predominant monoterpene indole alkaloid found in Alstonia scholaris, exhibits significant anti-tumor activity by inducing DNA fragmentation and apoptosis. Furthermore, it effectively inhibits pan...
TN4475	Macrocarpal C		ROS , Antifection
	Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associate...		ROS , Antifection
T73068	Mammea A/BA
	Mammea A/BA demonstrates significant efficacy in inhibiting Trypanosoma cruzi (T. cruzi), through mechanisms such as mitochondrial dysfunction, increased production of reactive oxygen species (ROS), and DNA fragmentation...
T35647	4-oxo-27-TBDMS Withaferin A
	4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/...